The significance of vascular photosensitization in photodynamic therapy

Barbara W. Henderson

doi:10.1117/12.2283674

21 January 1990 The significance of vascular photosensitization in photodynamic therapy

Barbara W. Henderson

Proceedings Volume 10306, Future Directions and Applications in Photodynamic Therapy; 103060C (1990) https://doi.org/10.1117/12.2283674
Event: SPIE Institutes for Advanced Optical Technologies 6, 1990, San Diego, California, United States

Abstract

Past research has shown that photodynamic therapy, using Photofrin II as sensitizer, exerts its tumor-destructive effects primarily through assault on the tissue microvasculature. This is accompanied by less than optimal treatment selectivity and prolonged normal tissue photo- sensitivity. The development of new sensitizers should therefore add to its goals of finding improved photochemical and photophysical characteristics the goal of increased tumor selectivity. The latter can only be achieved through detailed comparative studies of different second generation sensitizers, which will serve to unravel structure/function relationships and so lead to the rational design of new and truly superior compounds.

Citation Download Citation

Barbara W. Henderson "The significance of vascular photosensitization in photodynamic therapy", Proc. SPIE 10306, Future Directions and Applications in Photodynamic Therapy, 103060C (21 January 1990); https://doi.org/10.1117/12.2283674

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