Portable smartphone based quantitative phase microscope

Xin Meng; Xiaolin Tian; Wei Yu; Yan Kong; Zhilong Jiang; Fei Liu; Liang Xue; Cheng Liu; Shouyu Wang

doi:10.1117/12.2292034

12 January 2018 Portable smartphone based quantitative phase microscope

Xin Meng, Xiaolin Tian, Wei Yu, Yan Kong, Zhilong Jiang, Fei Liu, Liang Xue, Cheng Liu, Shouyu Wang

Proceedings Volume 10620, 2017 International Conference on Optical Instruments and Technology: Optoelectronic Imaging/Spectroscopy and Signal Processing Technology; 1062009 (2018) https://doi.org/10.1117/12.2292034
Event: International Conference on Optical Instruments and Technology 2017, 2017, Beijing, China

Abstract

To realize portable device with high contrast imaging capability, we designed a quantitative phase microscope using transport of intensity equation method based on a smartphone. The whole system employs an objective and an eyepiece as imaging system and a cost-effective LED as illumination source. A 3-D printed cradle is used to align these components. Images of different focal planes are captured by manual focusing, followed by calculation of sample phase via a self-developed Android application. To validate its accuracy, we first tested the device by measuring a random phase plate with known phases, and then red blood cell smear, Pap smear, broad bean epidermis sections and monocot root were also measured to show its performance. Owing to its advantages as accuracy, high-contrast, cost-effective and portability, the portable smartphone based quantitative phase microscope is a promising tool which can be future adopted in remote healthcare and medical diagnosis.

Citation Download Citation

Xin Meng, Xiaolin Tian, Wei Yu, Yan Kong, Zhilong Jiang, Fei Liu, Liang Xue, Cheng Liu, and Shouyu Wang "Portable smartphone based quantitative phase microscope", Proc. SPIE 10620, 2017 International Conference on Optical Instruments and Technology: Optoelectronic Imaging/Spectroscopy and Signal Processing Technology, 1062009 (12 January 2018); https://doi.org/10.1117/12.2292034

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