Studies On Laserthermia And PDT Using Nd:YAG Laser

K. Ina; H. Tsunekawa; M. Sugihara; M. Hotta; N. Mamiya; Y. Watanabe; N. Kanemaki; K. Morise; N. Daikuzono

doi:10.1117/12.952053

11 September 1989 Studies On Laserthermia And PDT Using Nd:YAG Laser

K. Ina, H. Tsunekawa, M. Sugihara, M. Hotta, N. Mamiya, Y. Watanabe, N. Kanemaki, K. Morise, N. Daikuzono

Proceedings Volume 1066, Laser Surgery: Advanced Characterization, Therapeutics, and Systems; (1989) https://doi.org/10.1117/12.952053
Event: OE/LASE '89, 1989, Los Angeles, CA, United States

Abstract

Photodynamic therapy (PDT) using laser has recently been demonstrated to be applicable for cancer treatment. The combination of Pheophorbide a (Ph-a) and pulsed Nd:YAG laser irradiation has enabled us to perform PDT with the same system as used in laser hyperthermia. We have investigated this new method using human neoplastic cell lines and we calculated the survival rates after laser irradiation. Next then, in order to determine the mechanism of photochemical action we measured lipid peroxide levels of cells and lastly, demonstrated the protective effects against PDT induced by chemical scavengers. We found that pulsed Nd:YAG laser irradiation with Ph-a caused a photochmical action in cell cultures, and active oxygen spieces and/or lipid perxide were likely involved in the photodynamic process.

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K. Ina, H. Tsunekawa, M. Sugihara, M. Hotta, N. Mamiya, Y. Watanabe, N. Kanemaki, K. Morise, and N. Daikuzono "Studies On Laserthermia And PDT Using Nd:YAG Laser", Proc. SPIE 1066, Laser Surgery: Advanced Characterization, Therapeutics, and Systems, (11 September 1989); https://doi.org/10.1117/12.952053

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