High temporal and spatial pattern stimulation to manipulate brain function

Hiroaki Wake; Koichiro Haruwaka; Kogyoku Zen; Osamu Matoba

doi:10.1117/12.2323184

24 April 2018 High temporal and spatial pattern stimulation to manipulate brain function

Hiroaki Wake, Koichiro Haruwaka, Kogyoku Zen, Osamu Matoba

Proceedings Volume 10711, Biomedical Imaging and Sensing Conference; 1071102 (2018) https://doi.org/10.1117/12.2323184
Event: SPIE Structured Light, 2018, Yokohama, Japan

Abstract

In the central nervous system (CNS), glial cells, originally termed “nervenkitt,” recently focused because of the understanding of their physiological functions. Here, we focused how glial cell regulates the function of neuronal circuits using in vivo two photon microscope. In this research, we visualized neural activity in the motor cortex during motor learning using in vivo two photon microscope to understand the abnormality of neural activity associated with impaired behavior output with myelin dysregulation. We further demonstrate the optogenetic stimulation to compensate the abnormal activity of neural activity to rescue the learning disability.

Citation Download Citation

Hiroaki Wake, Koichiro Haruwaka, Kogyoku Zen, and Osamu Matoba "High temporal and spatial pattern stimulation to manipulate brain function", Proc. SPIE 10711, Biomedical Imaging and Sensing Conference, 1071102 (24 April 2018); https://doi.org/10.1117/12.2323184

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