Targeting fatty acid synthase to inhibit tumor growth and overcome taxane resistance

Joshua J. Souchek; Lindsey Muraskin; Lucas Houser; Quyen Vu; Aaron M. Mohs

doi:10.1117/12.2512244

28 February 2019 Targeting fatty acid synthase to inhibit tumor growth and overcome taxane resistance

Joshua J. Souchek, Lindsey Muraskin, Lucas Houser, Quyen Vu, Aaron M. Mohs

Proceedings Volume 10859, Visualizing and Quantifying Drug Distribution in Tissue III; 1085909 (2019) https://doi.org/10.1117/12.2512244
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Aberrant metabolism mechanisms are a well-established hallmark of cancer. Exploiting tumor metabolism as a therapeutic target is being actively pursued. De novo synthesis of fatty acids by fatty acid synthase (FASN) is a particularly attractive mechanism to target because increased lipid synthesis is associated with more aggressive tumor. In particular, our work focuses on the reformulation of orlistat, an FDA-approved lipase inhibitor that also inhibits the thioesterase domain of FASN. We report on the rationale, synthesis, efficacy, delivery, and limitations of a novel nanoparticle formulation of orlistat in the goal of targeting the FASN pathway.

Conference Presentation

Citation Download Citation

Joshua J. Souchek, Lindsey Muraskin, Lucas Houser, Quyen Vu, and Aaron M. Mohs " Targeting fatty acid synthase to inhibit tumor growth and overcome taxane resistance", Proc. SPIE 10859, Visualizing and Quantifying Drug Distribution in Tissue III, 1085909 (28 February 2019); https://doi.org/10.1117/12.2512244

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