Bioessential chalcogenides and immunological applications: an in vitro exploration of Selenium nanoparticles as potential carriers and therapeutic agents (Conference Presentation)

Brandy Vincent; Chrismond Smith; Jonathan Mendoza; Ashley Tran; Justine Mendez; Rosemary Robledo; Kelly L. Nash

doi:10.1117/12.2513343

13 March 2019 Bioessential chalcogenides and immunological applications: an in vitro exploration of Selenium nanoparticles as potential carriers and therapeutic agents (Conference Presentation)

Brandy Vincent, Chrismond Smith, Jonathan Mendoza, Ashley Tran, Justine Mendez, Rosemary Robledo, Kelly L. Nash

Author Affiliations +

Proceedings Volume 10892, Colloidal Nanoparticles for Biomedical Applications XIV; 108920S (2019) https://doi.org/10.1117/12.2513343
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

In recent years, bioessential element-based chalcogenides, namely Selenium (Se) and Tellurium (Te), have established noted fundamentals as metal-based protective agents. In relation to anti-cancer therapeutics, Se in particular exhibits promising characteristics as potentially effective treatment alternatives due to its notoriety as a highly selective, drug-coordinating element. In addition to their competitive clinical resume, Se nanoparticles packaged as chalcogenides are believed to support anti-inflammatory, antimicrobial and antifungal efforts. Though more is needed to understand the biological effect these materials play within the body, studies postulate that there is significant potential for Se based nanoalloys. Partnering Se with elemental neighbor Te, SexTel-x, these alloys function as target mediators. They are believed to sustain cell viability ARPE-19 cells while initiating apoptotic effects on MDA-MB-453 cancer cells, along with promoting the reduction of reactive oxygen species (ROS) activity. Lastly, cellular integrity is maintained by the lack of DNA fragmentation within normal cells, further supporting the efforts of employing SexTel-x alloys as potential anti-cancer agents. Ultimately, this research will serve as fundamental currency marketing SexTel-x nanoalloys as synergistically compliant anti-inflammatory, anti-cancer therapeutic agents, priming the tone for treatment efficacy.

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Brandy Vincent, Chrismond Smith, Jonathan Mendoza, Ashley Tran, Justine Mendez, Rosemary Robledo, and Kelly L. Nash "Bioessential chalcogenides and immunological applications: an in vitro exploration of Selenium nanoparticles as potential carriers and therapeutic agents (Conference Presentation)", Proc. SPIE 10892, Colloidal Nanoparticles for Biomedical Applications XIV, 108920S (13 March 2019); https://doi.org/10.1117/12.2513343

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KEYWORDS

Selenium

Chalcogenides

Nanoparticles

Therapeutic agents

In vitro testing

Tellurium

Cancer

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