Optical monitoring of the meningeal lymphatic clearance after opening of blood-brain barrier

E. N. Duarte Torres; A. S. Abdurashitov; A. A. Namykin; A. A. Shirokov; N. A. Shushunova; A. P. Khorovodov; E. I. Sarantseva; O. V. Semyachkina-Glushkovskaya

doi:10.1117/12.2524427

3 June 2019 Optical monitoring of the meningeal lymphatic clearance after opening of blood-brain barrier

E. N. Duarte Torres, A. S. Abdurashitov, A. A. Namykin, A. A. Shirokov, N. A. Shushunova, A. P. Khorovodov, E. I. Sarantseva, O. V. Semyachkina-Glushkovskaya

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Proceedings Volume 11067, Saratov Fall Meeting 2018: Computations and Data Analysis: from Nanoscale Tools to Brain Functions; 1106713 (2019) https://doi.org/10.1117/12.2524427
Event: International Symposium on Optics and Biophotonics VI: Saratov Fall Meeting 2018, 2018, Saratov, Russian Federation

Abstract

In our experiments on rats we performed visualization of brain clearing from substances injected into the brain parenchyma using optical coherent tomography and fluorescence microscopy. Our results uncovered that the meningeal lymphatic system play an important role in the brain clearing processes, where the deep cervical lymph node is the first anatomical station of cerebral fluid exist from the brain. These data shed light on the novel mechanisms underlying drainage and clearing function of the brain.

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E. N. Duarte Torres, A. S. Abdurashitov, A. A. Namykin, A. A. Shirokov, N. A. Shushunova, A. P. Khorovodov, E. I. Sarantseva, and O. V. Semyachkina-Glushkovskaya "Optical monitoring of the meningeal lymphatic clearance after opening of blood-brain barrier", Proc. SPIE 11067, Saratov Fall Meeting 2018: Computations and Data Analysis: from Nanoscale Tools to Brain Functions, 1106713 (3 June 2019); https://doi.org/10.1117/12.2524427

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KEYWORDS

Lymphatic system

Brain

Tissues

Optical coherence tomography

Visualization

Luminescence

Microscopy

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