Gold nanoparticles-enhanced gold-silver alloy surface plasmon resonance sensor for the detection of C-reactive protein

Ru-meng Yi; Zhe Zhang; Chun-xiu Liu; Zhi-mei Qi

doi:10.1117/12.2534148

22 July 2019 Gold nanoparticles-enhanced gold-silver alloy surface plasmon resonance sensor for the detection of C-reactive protein

Ru-meng Yi, Zhe Zhang, Chun-xiu Liu, Zhi-mei Qi

Author Affiliations +

Proceedings Volume 11075, Novel Biophotonics Techniques and Applications V; 110751T (2019) https://doi.org/10.1117/12.2534148
Event: European Conferences on Biomedical Optics, 2019, Munich, Germany

Abstract

In this work, we developed a kind of gold-silver alloy film based surface plasmon resonance (AuAg-SPR) biosensors with wavelength interrogation to detect C-reaction protein (CRP) by using gold nanoparticles (AuNPs)-enhanced sandwich immunoassay, and the limit of detection (LOD) of CRP was found to be 5 pg/ml . In conclusion, using the AuNPsenhanced sandwich immunoassay and the SPR chip of AuAg alloy film can detect CRP effectively and reduce the LOD significantly, and this improvement can also be applied for the detection of any biomarkers in low concentration accurately.

Citation Download Citation

Ru-meng Yi, Zhe Zhang, Chun-xiu Liu, and Zhi-mei Qi "Gold nanoparticles-enhanced gold-silver alloy surface plasmon resonance sensor for the detection of C-reactive protein", Proc. SPIE 11075, Novel Biophotonics Techniques and Applications V, 110751T (22 July 2019); https://doi.org/10.1117/12.2534148

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