Method development and feasibility assessment for diagnosing 12 prostate needle cores within an hour of biopsy

Weisi Xie; Adam K. Glaser; Funda Vakar-Lopez; Nicholas P. Reder; Lawrence D. True; Jonathan T. C. Liu

doi:10.1117/12.2576959

5 March 2021 Method development and feasibility assessment for diagnosing 12 prostate needle cores within an hour of biopsy

Weisi Xie, Adam K. Glaser, Funda Vakar-Lopez, Nicholas P. Reder, Lawrence D. True, Jonathan T. C. Liu

Author Affiliations +

Proceedings Volume 11619, Advanced Photonics in Urology; 1161903 (2021) https://doi.org/10.1117/12.2576959
Event: SPIE BiOS, 2021, Online Only

Abstract

A current challenge is providing an accurate diagnosis in a timely manner for patients at risk of having prostate cancer. We developed and demonstrated a non-destructive procedure in which 12 biopsies can be cleared, fluorescently labeled, imaged with an open-top light-sheet (OTLS) microscope, and then diagnosed by a pathologist within an hour of biopsy. Using conventional histology as the gold standard, the accuracy, sensitivity, and specificity of 1Hr2Dx were all >90%. Such a method could potentially provide patients with a preliminary on-site diagnosis after a biopsy procedure, thereby alleviating anxiety and potentially expediting treatments.

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Citation Download Citation

Weisi Xie, Adam K. Glaser, Funda Vakar-Lopez, Nicholas P. Reder, Lawrence D. True, and Jonathan T. C. Liu "Method development and feasibility assessment for diagnosing 12 prostate needle cores within an hour of biopsy", Proc. SPIE 11619, Advanced Photonics in Urology, 1161903 (5 March 2021); https://doi.org/10.1117/12.2576959

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