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The development and application of adaptive optics (AO) in retinal imaging have enabled visualization of a plethora of retinal cells and structures. However, major hurdles exist for translating these achievements to the widely-available clinical devices for broad clinical applications. Here, by configuring a research grade AO – optical coherence tomography (AO-OCT) system to simulate a clinical OCT device, we provide evidence that clinical OCT systems have the potential to resolve individual ganglion cell layer somas and determine that a lateral sampling of ~1.5 µm/pixel is required to accurately quantify soma density and size.
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Furu Zhang, Catherine A. Cukras, Daniel X. Hammer, Zhuolin Liu, "Towards in vivo imaging of ganglion cell layer somas using widely-available clinical OCT devices," Proc. SPIE 11623, Ophthalmic Technologies XXXI, 116230Y (5 March 2021); https://doi.org/10.1117/12.2582785