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5 March 2021 Intrinsic signal optoretinography of photoreceptor phototransduction and energy metabolism
Guangying Ma, Taeyun Son, Tae-Hoon Kim, Xincheng Yao
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Proceedings Volume 11623, Ophthalmic Technologies XXXI; 1162316 (2021) https://doi.org/10.1117/12.2577080
Event: SPIE BiOS, 2021, Online Only
Abstract
This study is to characterize intrinsic optical signal (IOS) changes in the photoreceptor outer segment (OS) and inner segment (IS). Functional optical coherence tomography (OCT) was used for in vivo IOS imaging of wild-type mice (C57BL/6J). Depth-resolved OCT revealed stimulus-evoked IOSs at individual retinal layers, with sub-photoreceptor resolution. Rapid IOS response occurred in the OS region immediately after the stimulus onset. In contrast, transient IOS showed a time delay and gradually increased in the IS region. We anticipate that the OS-IOS and IS-IOS can work as objective biomarkers to reflect photoreceptor phototransduction and metabolism property, respectively.
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Guangying Ma, Taeyun Son, Tae-Hoon Kim, and Xincheng Yao "Intrinsic signal optoretinography of photoreceptor phototransduction and energy metabolism", Proc. SPIE 11623, Ophthalmic Technologies XXXI, 1162316 (5 March 2021); https://doi.org/10.1117/12.2577080
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KEYWORDS
Optical coherence tomography
Image segmentation
Eye
Information operations
In vivo imaging
Mode conditioning cables
Retinal scanning
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