Pain modulation by multi-characteristic opsin sensitization of inhibitory network of brain

Darryl Narcisse; Robert Benkowski; Arman Fijany; Samarendra K. Mohanty

doi:10.1117/12.2586107

5 March 2021 Pain modulation by multi-characteristic opsin sensitization of inhibitory network of brain

Darryl Narcisse, Robert Benkowski, Arman Fijany, Samarendra K. Mohanty

Proceedings Volume 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics; 1162914 (2021) https://doi.org/10.1117/12.2586107
Event: SPIE BiOS, 2021, Online Only

Abstract

Here, we report development of AAV-carried therapeutic gene construct consisting of cell-specific promoter driven Multi-Characteristic Opsin (MCO-II) to target inhibitory cells of ACC. MCO-II is highly sensitive to light and can be activated at low intensity, thus requiring a very low power budget. This along with red-light sensitiveness of MCO allows deep penetration with a minimally invasive implant. We developed a wireless Bluetooth Optogenetic Pain Modulator device for control of the dose of optogenetic stimulation. We demonstrated that red light stimulation of inhibitory neurons in ACC expressing MCO-II leads to significant reduction in pain response in fully awake animals.

Conference Presentation

Citation Download Citation

Darryl Narcisse, Robert Benkowski, Arman Fijany, and Samarendra K. Mohanty "Pain modulation by multi-characteristic opsin sensitization of inhibitory network of brain", Proc. SPIE 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics, 1162914 (5 March 2021); https://doi.org/10.1117/12.2586107

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