Early stage, label-free detection of breast cancer based on exosome’s protein content alteration

Mandana Jalali; Daniel Erni

doi:10.1117/12.2621062

17 May 2022 Early stage, label-free detection of breast cancer based on exosome’s protein content alteration

Mandana Jalali, Daniel Erni

Proceedings Volume 12139, Optical Sensing and Detection VII; 121390G (2022) https://doi.org/10.1117/12.2621062
Event: SPIE Photonics Europe, 2022, Strasbourg, France

Abstract

In this work, the protein content alteration in cancerous versus healthy exosomes is used as the figure of merit in an early stage, label-free, non-invasive, liquid biopsy based cancer diagnosis biosensing method. To do so, an anisotropic effective refractive index is assigned to the exosome, which determines its protein content, according to a minute 3D model of the exosome based on the mean field theory. The modeled exosomes are then positioned in the vicinity of a polymer coated spherical microresonator, capable of distinguishing such slight refractive index alteration. Such ultra-sensitivity is achieved due to adding the shell as it reduces the radiation loss together with the mode volume. Results show that, increasing the amount of protein content in the exosome by even 1%, as a potential cancer biomarker, concludes to 3.5fm wavelength shift in the whispering gallery resonance of the microresonator, and accordingly facilitating early stage cancer diagnosis in a label-free manner.

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Citation Download Citation

Mandana Jalali and Daniel Erni "Early stage, label-free detection of breast cancer based on exosome’s protein content alteration", Proc. SPIE 12139, Optical Sensing and Detection VII, 121390G (17 May 2022); https://doi.org/10.1117/12.2621062

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