Preliminary study on photodynamic effect of intense pulsed light (IPL) excitation of porphyrin photosensitizer

Xin Wang; Zheng Zou; Weijin Peng; Cheng Ke; Zheng Huang; Min Li

doi:10.1117/12.2643727

19 December 2022 Preliminary study on photodynamic effect of intense pulsed light (IPL) excitation of porphyrin photosensitizer

Xin Wang, Zheng Zou, Weijin Peng, Cheng Ke, Zheng Huang, Min Li

Author Affiliations +

Proceedings Volume 12320, Optics in Health Care and Biomedical Optics XII; 1232015 (2022) https://doi.org/10.1117/12.2643727
Event: SPIE/COS Photonics Asia, 2022, Online Only

Abstract

Intense pulsed light (IPL) is an incoherent high-intensity pulsed light and early studies suggest that it might be used in photodynamic therapy (PDT). This study investigated the feasibility of using IPL combined with Hemporfin, a porphyrin-type photosensitizer. The photodynamic effects of two IPL light sources (560-1200 nm and 640-1200 nm) were determined by photobleaching of Hemporfin and Hemporfin-mediated cell killing experiments. Results showed that when combined with Hemoporfin both IPLs could generate photodynamic effects. Therefore, it is feasible to use IPL as PDT light source.

Conference Presentation

Citation Download Citation

Xin Wang, Zheng Zou, Weijin Peng, Cheng Ke, Zheng Huang, and Min Li "Preliminary study on photodynamic effect of intense pulsed light (IPL) excitation of porphyrin photosensitizer", Proc. SPIE 12320, Optics in Health Care and Biomedical Optics XII, 1232015 (19 December 2022); https://doi.org/10.1117/12.2643727

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