Use of FCCS in drug discovery and development and presentation of a novel dedicated instrument for industrial FCCS applications

Frank Becker

doi:10.1117/12.2650018

15 March 2023 Use of FCCS in drug discovery and development and presentation of a novel dedicated instrument for industrial FCCS applications

Frank Becker

Author Affiliations +

Proceedings Volume 12386, Single Molecule Spectroscopy and Superresolution Imaging XVI; 1238607 (2023) https://doi.org/10.1117/12.2650018
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

FCCS (fluorescence cross correlation spectroscopy) is a powerful tool to characterize drug target interaction in physiological environments. Over the last decade this technology was used to understand the binding and kinetics of small molecules and antibodies to challenging target proteins in great details and accuracy. Over the last decade Intana Bioscience expanded the application of FCCS from affinity measurements to comprehensive interaction studies including kinetics, multi component complex formation, assessing stoichiometry and quantification of aggregation, PK studies and target engagement. This presentation will highlight examples of results obtained with FCCS in projects ranging from early stages in the drug discovery up to the support of clinical trials to quantify target occupancies in patient samples.

Conference Presentation

Citation Download Citation

Frank Becker "Use of FCCS in drug discovery and development and presentation of a novel dedicated instrument for industrial FCCS applications", Proc. SPIE 12386, Single Molecule Spectroscopy and Superresolution Imaging XVI, 1238607 (15 March 2023); https://doi.org/10.1117/12.2650018

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available