Performance assessment of a focussed gamma probe using Monte Carlo simulations

Sydney L. M. Wilson; Claire Park; Hristo N. Nikolov; Jaques Milner; David W. Holdsworth

doi:10.1117/12.2655035

7 April 2023 Performance assessment of a focussed gamma probe using Monte Carlo simulations

Sydney L. M. Wilson, Claire Park, Hristo N. Nikolov, Jaques Milner, David W. Holdsworth

Proceedings Volume 12463, Medical Imaging 2023: Physics of Medical Imaging; 1246345 (2023) https://doi.org/10.1117/12.2655035
Event: SPIE Medical Imaging, 2023, San Diego, California, United States

Conference Poster

Abstract

Non-imaging gamma probes are frequently used in radioguided surgery to provide intraoperative localization of radiolabeled tissue, however, most of these probes have a single-hole, cylindrical collimator that suffers from increasingly poor resolution and sensitivity with an increase in distance from the radioactive source. As such, these existing probes are not always suitable in situations where two radiolabeled structures are in close proximity, or a boundary between radiolabeled and normal tissue must be precisely identified. To circumvent these problems, we previously designed a highly convergent collimator that provided high-resolution spot detection of a radioactive source in a remote focal zone, 35 mm away from the collimator face. The purpose of this study was to incorporate the convergent collimator into a custom designed Focussed Gamma Probe (FGP) and assess its performance using Monte Carlo simulations in an open-source software package (GATE). The FGP has a thallium-doped cesium iodide scintillation crystal coupled to a silicon photomultiplier, with all components assembled in a hand-held package. We found that the FGP had a simulated FWHM resolution of 3.2 mm, sensitivity of 3.5 cps/kBq, and shielding effectiveness of 99.9% at 35 keV, and similarly a FWHM resolution of 3.3 mm, sensitivity of 5.3 cps/kBq, and shielding effectiveness of 98.7% at 140 keV. The FGP showed comparable sensitivity and a 10-fold improvement in resolution compared to existing gamma probes when a radioactive source is located 30 mm away from the probe tip, thus indicating that the FGP should be feasible for use in radioguided surgery.

Citation Download Citation

Sydney L. M. Wilson, Claire Park, Hristo N. Nikolov, Jaques Milner, and David W. Holdsworth "Performance assessment of a focussed gamma probe using Monte Carlo simulations", Proc. SPIE 12463, Medical Imaging 2023: Physics of Medical Imaging, 1246345 (7 April 2023); https://doi.org/10.1117/12.2655035

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