Closed-loop feedback control for droplet-based microfluidics: a characteristic investigation on passive and on-demand droplet generation

Xiudong Duan; Zhou Zheng; Yingdong Luo; Chaolong Song

doi:10.1117/12.2666602

27 January 2023 Closed-loop feedback control for droplet-based microfluidics: a characteristic investigation on passive and on-demand droplet generation

Xiudong Duan, Zhou Zheng, Yingdong Luo, Chaolong Song

Author Affiliations +

Proceedings Volume 12550, International Conference on Optical and Photonic Engineering (icOPEN 2022); 125500W (2023) https://doi.org/10.1117/12.2666602
Event: International Conference on Optical and Photonic Engineering (icOPEN 2022), 2022, ONLINE, China

Abstract

Droplet-based microfluidics is an emerging interdisciplinary field with broad applications. Accurate control of droplet volumes allows to perform quantitative detection with high throughput. But there are still many issues with the precision and practicability of droplet generation when the device suffers from inevitable disturbances or pressure oscillations. When the droplets of certain sizes are further desired, the passive system cannot generate droplets accurately and uniformly with a significant deviation between the actual volume and target. In this work, we propose the usage of Quantitative Phase Imaging (QPI) technique for real-time detection of flowing droplets, which can provide a precise 3-D measurement of droplet volume as a feedback signal. Incorporated with a closed-loop feedback control scheme to constantly monitor the instantaneous volume error and regulate fluidic pressures to keep the droplet size towards the setpoint value. The PID feedback control can develop higher accuracy and monodispersity of on-demand droplet generation, together with enhanced stability to resist internal or external perturbations, which could promise a predictable outcome in complex conditions of practical microfluidics-based systems.

Citation Download Citation

Xiudong Duan, Zhou Zheng, Yingdong Luo, and Chaolong Song "Closed-loop feedback control for droplet-based microfluidics: a characteristic investigation on passive and on-demand droplet generation", Proc. SPIE 12550, International Conference on Optical and Photonic Engineering (icOPEN 2022), 125500W (27 January 2023); https://doi.org/10.1117/12.2666602

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KEYWORDS

Feedback control

Microfluidics

3D image processing

Feedback signals

3D metrology

Beam splitters

Control systems

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