μLED arrays for optogenetic stimulation of the mouse auditory cortical surface

Ryan Greer; Antonin Verdier; Emma Butt; Yunzhou Cheng; Niall McAlinden; Brice Bathellier; Keith Mathieson

doi:10.1117/12.3005267

13 March 2024 μLED arrays for optogenetic stimulation of the mouse auditory cortical surface

Ryan Greer, Antonin Verdier, Emma Butt, Yunzhou Cheng, Niall McAlinden, Brice Bathellier, Keith Mathieson

Proceedings Volume 12829, Optogenetics and Optical Manipulation 2024; 128290B (2024) https://doi.org/10.1117/12.3005267
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Cortical surface stimulators are an application of µLEDs allowing spatiotemporal stimulation of genetically targeted populations of neurons in the cerebral cortex. To address challenges with the spatial resolution and density of stimulation sites, a high-precision 100-pixel µLED device was developed. The device consists of a 10 x 10 matrix addressed array of GaN µLEDs with 200 µm spacing, which emit blue light at 450 nm through a sapphire substrate. In-vivo experiments in the auditory cortex of ChR2-expressing transgenic mice have shown consistent multi-unit activity with low µLED drive current and low lateral spread of activation.

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Citation Download Citation

Ryan Greer, Antonin Verdier, Emma Butt, Yunzhou Cheng, Niall McAlinden, Brice Bathellier, and Keith Mathieson "μLED arrays for optogenetic stimulation of the mouse auditory cortical surface", Proc. SPIE 12829, Optogenetics and Optical Manipulation 2024, 128290B (13 March 2024); https://doi.org/10.1117/12.3005267

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KEYWORDS

Optogenetics

Auditory cortex

Light emitting diodes

Neurons

Matrices

Microfabrication

Patterned sapphire substrate

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