Acute vasculature disruption in orthotopic kidney tumors based on vascular disrupting agent (OXi8007) examined by multispectral optoacoustic tomography (MSOT)

Hashini I. Wanniarachchi; Lorena M. A. Bueno; Ricardo Rayas; Khagendra B. Hamal; Cyprian I. Pavlich; Mary Lynn Trawick; Kevin G. Pinney; Li Liu; Ralph P. Mason

doi:10.1117/12.3001850

12 March 2024 Acute vasculature disruption in orthotopic kidney tumors based on vascular disrupting agent (OXi8007) examined by multispectral optoacoustic tomography (MSOT)

Hashini I. Wanniarachchi, Lorena M. A. Bueno, Ricardo Rayas, Khagendra B. Hamal, Cyprian I. Pavlich, Mary Lynn Trawick, Kevin G. Pinney, Li Liu, Ralph P. Mason

Author Affiliations +

Proceedings Volume 12842, Photons Plus Ultrasound: Imaging and Sensing 2024; 128420A (2024) https://doi.org/10.1117/12.3001850
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Multispectral optoacoustic tomography (MSOT) provides anatomical and functional imaging of tissues without the need for reporter molecules or transfection. We examined the acute vascular disrupting activity of a new microtubule disrupting agent (OXi8007) using MSOT on syngeneic mouse RENCA-luc, and human XP258 orthotopic kidney tumors. In both tumor types, an oxygen gas breathing challenge showed reduced tumor oxygenation and response within 4h of treatment. In RENCA-luc tumors this matched vascular shutdown assessed by dynamic BLI. MSOT additionally confirmed that VDA did not significantly affect the contralateral normal kidney or spine.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Hashini I. Wanniarachchi, Lorena M. A. Bueno, Ricardo Rayas, Khagendra B. Hamal, Cyprian I. Pavlich, Mary Lynn Trawick, Kevin G. Pinney, Li Liu, and Ralph P. Mason "Acute vasculature disruption in orthotopic kidney tumors based on vascular disrupting agent (OXi8007) examined by multispectral optoacoustic tomography (MSOT)", Proc. SPIE 12842, Photons Plus Ultrasound: Imaging and Sensing 2024, 128420A (12 March 2024); https://doi.org/10.1117/12.3001850

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available