Manipulating light for the detection of viruses in resource-limited settings

Abraham J. Qavi; Qisheng Zhang; M. Javad Aman; Hong Vu; Larry Zetlin; John M. Dye; Jeffrey W. Froude; Daisy W. Leung; Frederick Holtsberg; Scott L. Crick; Gaya Amarasinghe

doi:10.1117/12.3002153

13 March 2024 Manipulating light for the detection of viruses in resource-limited settings

Abraham J. Qavi, Qisheng Zhang, M. Javad Aman, Hong Vu, Larry Zetlin, John M. Dye, Jeffrey W. Froude, Daisy W. Leung, Frederick Holtsberg, Scott L. Crick, Gaya Amarasinghe

Author Affiliations +

Proceedings Volume 12861, Frontiers in Biological Detection: From Nanosensors to Systems XVI; 128610B (2024) https://doi.org/10.1117/12.3002153
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Neglected tropical diseases, including filoviruses, constitute a class of diseases affecting some of the most impoverished and vulnerable populations worldwide. Despite their significant impact, there is a pressing need for diagnostics that can effectively and rapidly detect pathogens in field settings. Herein, we present a portable diagnostic platform leveraging plasmonic fluors and lateral flow assays for the detection of filoviruses. Plasmonic fluors are a class of engineered, ultrabright fluorescent probes whose versatility and amenability towards use in a variety of diagnostics is a major clinical strength. Our resulting assay has a rapid turnaround time and sensitivities amenable for field deployment.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Abraham J. Qavi, Qisheng Zhang, M. Javad Aman, Hong Vu, Larry Zetlin, John M. Dye, Jeffrey W. Froude, Daisy W. Leung, Frederick Holtsberg, Scott L. Crick, and Gaya Amarasinghe "Manipulating light for the detection of viruses in resource-limited settings", Proc. SPIE 12861, Frontiers in Biological Detection: From Nanosensors to Systems XVI, 128610B (13 March 2024); https://doi.org/10.1117/12.3002153

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