A meta-analysis of progress in liquid biomarker-based diagnostic studies of Alzheimer's disease

Haomeng Liu

doi:10.1117/12.3012991

8 January 2024 A meta-analysis of progress in liquid biomarker-based diagnostic studies of Alzheimer's disease

Haomeng Liu

Proceedings Volume 12924, Third International Conference on Biological Engineering and Medical Science (ICBioMed2023); 129240K (2024) https://doi.org/10.1117/12.3012991
Event: 3rd International Conference on Biological Engineering and Medical Science (ICBioMed2023), 2023, ONLINE, United Kingdom

Abstract

The accurate diagnosis of Alzheimer's disease is of great importance in clinical treatment and research. In this paper, the effect sizes of different biomarkers in the ALZBIOMARKER database were mapped and analyzed based on the MATLAB platform. The results found that CSF biomarkers (tau protein, Aβ42, NFL) and plasma (or serum) biomarkers (tau-181, NFL, GFAP) were strongly associated with Alzheimer's disease; among them, the core biomarkers (tau protein, Aβ42) were strongly associated with mild cognitive impairment. The emerging CSF biomarkers NSE, VLP-1, HFABP and YKL- 40 were moderately associated with Alzheimer's disease. T-tau, P-tau, Aβ42 and NFL in CSF were found to be useful for clinical practice and research through analysis.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Haomeng Liu "A meta-analysis of progress in liquid biomarker-based diagnostic studies of Alzheimer's disease", Proc. SPIE 12924, Third International Conference on Biological Engineering and Medical Science (ICBioMed2023), 129240K (8 January 2024); https://doi.org/10.1117/12.3012991

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