Exploring the effect of polygonum multiflorum Thunb on Aβ1-42 oligomer-burdened microglia model for Alzheimer’s disease based on network pharmacology and experiments in vitro

Yifei Zuo; Jonathan Yang

doi:10.1117/12.3021821

8 January 2024 Exploring the effect of polygonum multiflorum Thunb on Aβ_1-42 oligomer-burdened microglia model for Alzheimer’s disease based on network pharmacology and experiments in vitro

Yifei Zuo, Jonathan Yang

Author Affiliations +

Proceedings Volume 12924, Third International Conference on Biological Engineering and Medical Science (ICBioMed2023); 1292416 (2024) https://doi.org/10.1117/12.3021821
Event: 3rd International Conference on Biological Engineering and Medical Science (ICBioMed2023), 2023, ONLINE, United Kingdom

Abstract

Alzheimer’s disease (AD) is the most common degenerative disease of the central nervous system, with an increasing death rate but no effective treatment strategy. Traditional Chinese medicine (TCM) is becoming an attractive alternative approach for the understanding and cleaning of amyloid β (Aβ) accumulation in AD. Polygonum multiflorum Thunb (Heshouwu) has been widely reported to be effective for AD via meta-analysis and network pharmacology. Rhein in Polygonum multiflorum Thunb was isolated as the most promising chemical compound with the highest potential in producing anti-oxidative results. Microglia cell lines were utilized in trials to assess mitochondrial availability. To explore the effect and mechanism of Rhein on AD treatment, Aβ1-42 oligomer-burdened microglia cell line model was constructed. Rhein was found effective in reducing the inflammatory activation of microglia caused by Aβ1-42 oligomer incubation and alleviating microglial mitochondrial dysfunction resulting from Aβ1-42 oligomer incubation. Our study is the first to demonstrate Rhein’s therapeutic effects on neuroinflammation caused by microglia. This finding further supports the feasibility of Polygonum Multiflorum Thunb, a TCM, as a potential drug for AD treatment. These results broaden our knowledge of improving mitochondrial function as an approach for relieving microglia oxidative and overactivation stress in AD.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

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Yifei Zuo and Jonathan Yang "Exploring the effect of polygonum multiflorum Thunb on Aβ_1-42 oligomer-burdened microglia model for Alzheimer’s disease based on network pharmacology and experiments in vitro", Proc. SPIE 12924, Third International Conference on Biological Engineering and Medical Science (ICBioMed2023), 1292416 (8 January 2024); https://doi.org/10.1117/12.3021821

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