Light-emitting diode source for photodynamic therapy

A. Charles Lytle; Brian K. Dalton; Daniel R. Doiron; Rick W. Keck; Steven H. Selman M.D.; Miriam E. Wagoner

doi:10.1117/12.146308

18 June 1993 Light-emitting diode source for photodynamic therapy

A. Charles Lytle, Brian K. Dalton, Daniel R. Doiron, Rick W. Keck, Steven H. Selman M.D., Miriam E. Wagoner

Proceedings Volume 1881, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy II; (1993) https://doi.org/10.1117/12.146308
Event: OE/LASE'93: Optics, Electro-Optics, and Laser Applications in Scienceand Engineering, 1993, Los Angeles, CA, United States

Abstract

Lasers have traditionally been the preferred light source for activation of the photosensitizing agents used in photodynamic therapy (PDT). Their monochromaticity, high power, and the ability to couple that high power into optical fibers have dictated their use. There are however, many potential applications for PDT which do not require fiberoptic light delivery, and thus, need not incur the high cost associated with the use of laser systems. Treatment of skin cancer, cervical cancer, and cancers in the oral cavity could be effectively treated with alternative light sources, which would greatly reduce the cost of treatment. This paper will describe the features of a preclinical light emitting diode (LED) based source for photodynamic therapy, designed and built by PDT Systems. The results of an animal study, using the photosensitizer SnET2 activated at 660 nm, which compared the efficacy of PDT performed with a dye laser system with that of the LED system will be presented. Future plans for a clinical version of the LED system will also be discussed.

Citation Download Citation

A. Charles Lytle, Brian K. Dalton, Daniel R. Doiron, Rick W. Keck, Steven H. Selman M.D., and Miriam E. Wagoner "Light-emitting diode source for photodynamic therapy", Proc. SPIE 1881, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy II, (18 June 1993); https://doi.org/10.1117/12.146308

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