Quantitative data on blood flow during tumor PDT obtained by laser Doppler spectroscopy in the hen's egg test system

Anja Vervoorts; H. Achim Rood; Marcus Klotz; Joerg G. Moser; Martin Rosenbruch

doi:10.1117/12.199175

12 January 1995 Quantitative data on blood flow during tumor PDT obtained by laser Doppler spectroscopy in the hen's egg test system

Anja Vervoorts, H. Achim Rood, Marcus Klotz, Joerg G. Moser, Martin Rosenbruch

Author Affiliations +

Proceedings Volume 2325, Photodynamic Therapy of Cancer II; (1995) https://doi.org/10.1117/12.199175
Event: International Symposium on Biomedical Optics Europe '94, 1994, Lille, France

Abstract

Oxygen supply is the most important requirement of type II photodynamic reactions. Prerequisite in photodynamic tumor therapy is an intact tumor blood flow during irradiation. Most photosensitizers destroy tumor vessels due to accumulation in endothelial cells. As a prerequisite to develop novel photosensitizing drugs an in-vivo test system is required to quantitatively assess for inertness of those sensitizers to the blood supply. We adapted and further developed a system capable of measuring the relative oxygen supply to heterotransplanted tumors on the yolk sac membrane (YSM) of fertilized chicken eggs.

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Anja Vervoorts, H. Achim Rood, Marcus Klotz, Joerg G. Moser, and Martin Rosenbruch "Quantitative data on blood flow during tumor PDT obtained by laser Doppler spectroscopy in the hen's egg test system", Proc. SPIE 2325, Photodynamic Therapy of Cancer II, (12 January 1995); https://doi.org/10.1117/12.199175

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