Synthetic approaches to long-wavelength photosensitizers for photodynamic therapy and their preliminary biological activity

R. K. Pandey; Nadine Jagerovic; Thomas J. Dougherty; Kevin M. Smith

doi:10.1117/12.199130

12 January 1995 Synthetic approaches to long-wavelength photosensitizers for photodynamic therapy and their preliminary biological activity

R. K. Pandey, Nadine Jagerovic, Thomas J. Dougherty, Kevin M. Smith

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Proceedings Volume 2325, Photodynamic Therapy of Cancer II; (1995) https://doi.org/10.1117/12.199130
Event: International Symposium on Biomedical Optics Europe '94, 1994, Lille, France

Abstract

The chlorophyll-a degradation product, purpurin-18 methyl ester (4), was converted into a series of new bacteriochlorins (18)-(20). These stable bacteriochlorins have strong long- wavelength absorptions > 800 nm, and were tested for in vivo photosensitizing activity using the standard screening system of DBA/2 mice bearing transplanted SMT/F tumors. In preliminary screening, among the photosensitizers tested so far, bacteriochlorins (19) and (20) have shown promising anti-tumor activity. Preliminary attempts are described, using photo- Fenton chemistry, to synthesize photosensitizers which display both Type-I and Type-II photochemical behavior.

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R. K. Pandey, Nadine Jagerovic, Thomas J. Dougherty, and Kevin M. Smith "Synthetic approaches to long-wavelength photosensitizers for photodynamic therapy and their preliminary biological activity", Proc. SPIE 2325, Photodynamic Therapy of Cancer II, (12 January 1995); https://doi.org/10.1117/12.199130

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