Steady state and time-resolved absorption spectroscopy of porphyrins aggregates: relation to photosensitized tumor therapy

Ricardas Rotomskis; Giedre Streckyte; Janina Didziapetriene

doi:10.1117/12.197409

2 January 1995 Steady state and time-resolved absorption spectroscopy of porphyrins aggregates: relation to photosensitized tumor therapy

Ricardas Rotomskis, Giedre Streckyte, Janina Didziapetriene

Author Affiliations +

Proceedings Volume 2370, 5th International Conference on Laser Applications in Life Sciences; (1995) https://doi.org/10.1117/12.197409
Event: Laser Applications in Life Sciences: 5th International Conference, 1994, Minsk, Belarus

Abstract

Hematoporphyrins and related species used in photosensitized tumor therapy (PTT) were revealed to be mixtures of monomers, dimers and aggregates. In this paper we present steady state and time-resolved absorption spectroscopy data about the structure of hematoporphyrins aggregates, and energy relaxation pathways of individual components of a complex mixture of different aggregated species. The activity of hematoporphyrin derivative (HpD) and dimethoxyhematoporphyrin (DMHp) in PTT was studied. Antitumor efficiency of HpD and DMHp in PTT is similar, but HpD expresses better therapeutic effect, and it is probably due to the positive influence of covalently linked structures present in the solutions of HpD on the organisms.

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Ricardas Rotomskis, Giedre Streckyte, and Janina Didziapetriene "Steady state and time-resolved absorption spectroscopy of porphyrins aggregates: relation to photosensitized tumor therapy", Proc. SPIE 2370, 5th International Conference on Laser Applications in Life Sciences, (2 January 1995); https://doi.org/10.1117/12.197409

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