Pharmacokinetics of 2,4-di(alpha-methoxyethyl)deuteroporphyrin-IX (dimehin) and its complex with chitosan in mice with tumors

Andrei V. Ivanov; A. T. Gradyushko; V. P. Laptev; N. G. Panferova; V. P. Varlamov; B. A. Klyashchitsky; Andrei V. Reshetnickov; Gelii V. Ponomarev

doi:10.1117/12.229486

8 January 1996 Pharmacokinetics of 2,4-di(alpha-methoxyethyl)deuteroporphyrin-IX (dimehin) and its complex with chitosan in mice with tumors

Andrei V. Ivanov, A. T. Gradyushko, V. P. Laptev, N. G. Panferova, V. P. Varlamov, B. A. Klyashchitsky, Andrei V. Reshetnickov, Gelii V. Ponomarev

Author Affiliations +

Proceedings Volume 2728, CIS Selected Papers: Laser Use in Oncology; (1996) https://doi.org/10.1117/12.229486
Event: CIS Selected Papers: Laser Use in Oncology, 1995, -, Russian Federation

Abstract

The kinetics of photosensitizer distribution and elimination have been studied using fluorescent methods in organs and tumors of A/Snell mice with embriocarcinoma inoculated into their thigh muscles for the porphyrin compound 2,4-di((alpha) -methoxyethyl)deuteroporphyrin-- IX (DMH, `Dimehin') and its complex with polysaccharide chitosan. DMH fluorescence differs in samples of liver and faeces which follows from the spectra comparison. DMH is metabolizable upon passing through liver into a form eliminated by the gastrointestinal tract as our pharmacokinetic data have shown. DMH has been found to be a short-term highly photodynamically efficient photosensitizer judging by combined analysis of our toxicological, pharmacokinetic and photodynamic research data. DMH-chitosan uptake and distribution studies have shown the complex's long-term persistence in blood circulation, high level accumulation in spleen and lungs, whereas there was no complex registered in tumors and other tissues following i.v. administration.

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Andrei V. Ivanov, A. T. Gradyushko, V. P. Laptev, N. G. Panferova, V. P. Varlamov, B. A. Klyashchitsky, Andrei V. Reshetnickov, and Gelii V. Ponomarev "Pharmacokinetics of 2,4-di(alpha-methoxyethyl)deuteroporphyrin-IX (dimehin) and its complex with chitosan in mice with tumors", Proc. SPIE 2728, CIS Selected Papers: Laser Use in Oncology, (8 January 1996); https://doi.org/10.1117/12.229486

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