Second-generation photosensitizers based on natural chlorines and bacteriochlorines

Andrei F. Mironov

doi:10.1117/12.229483

8 January 1996 Second-generation photosensitizers based on natural chlorines and bacteriochlorines

Andrei F. Mironov

Proceedings Volume 2728, CIS Selected Papers: Laser Use in Oncology; (1996) https://doi.org/10.1117/12.229483
Event: CIS Selected Papers: Laser Use in Oncology, 1995, -, Russian Federation

Abstract

New sensitizers for photodynamic therapy were synthesized on the base of biologically generated chlorins and bacteriochlorins. Derivatives of chlorophyll a and bacteriochlorophyll were prepared from the biomass of blue-green algae Spirulina Platensis and purple bacteria Rhodobacter Capsulatus, generated using specially designed photobioreactor. The strategy for chemical transformation of natural chlorophylls and bacteriochlorophyll has been discussed. Purpurin 18 and its dihydroanalogue bacteriopurpurin were chosen as the key intermediates. Modifications of peripheral substituents, such as introducing the new functional groups, hydrogenation of the B-pyrrolic ring, and insertion of amino acid residues gave the series of novel sensitizers, including water soluble chlorin p₆ analogues, and derivatives with graded amphiphility for the studies of tumor accumulation in the malignant tissues.

Citation Download Citation

Andrei F. Mironov "Second-generation photosensitizers based on natural chlorines and bacteriochlorines", Proc. SPIE 2728, CIS Selected Papers: Laser Use in Oncology, (8 January 1996); https://doi.org/10.1117/12.229483

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