Morphological changes after Nd:YAG laser treatment of the human prostate with the SideFocus fiber: correlation to MRI and impact of dosimetry and time

Tullio Sulser; Wolfram Jochum; Rahel Huch Boni; Gabriel P. Krestin; Philipp U. Heitz; Dieter Hauri

doi:10.1117/12.275070

22 May 1997 Morphological changes after Nd:YAG laser treatment of the human prostate with the SideFocus fiber: correlation to MRI and impact of dosimetry and time

Tullio Sulser, Wolfram Jochum, Rahel Huch Boni, Gabriel P. Krestin, Philipp U. Heitz, Dieter Hauri

Author Affiliations +

Proceedings Volume 2970, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII; (1997) https://doi.org/10.1117/12.275070
Event: BiOS '97, Part of Photonics West, 1997, San Jose, CA, United States

Abstract

Determination of optimal treatment parameters and appropriate methods of examination for Nd:YAG laser coagulation of the human prostate in dependence of power-setting and time using the SideFocus^R side-firing delivery system. Transurethral free-beam laser coagulation was performed in 10 patients prior to planned radical prostatectomy. Thereof 6 underwent laparoscopic lymphadenectomy and laser coagulation of the prostate between 4 and 9 days prior to open surgery. These same patients had undergone MRI-examination with an endorectal coil during staging and prior to radical prostatectomy. Depth and volume of coagulated prostatic tissue of a 4-quadrant laser application were measured at power settings of 40 W/90 s and 60 W/60 s. There was no difference in volume coagulation between the two treatment modalities. In contrast there was a significant difference in volume coagulation between those prostates removed at 4 to 9 days and those removed t 60 to 210 minutes after laser coagulation. In histological and MRI- examination, however, there was a strong correlation with view to coagulation volume. Both treatment modalities showed comparable volume coagulation with laser induced changes conclusively discernible by 4 days. MRI-examination with an endorectal coil proved to be perfectly suitable for assessment.

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Tullio Sulser, Wolfram Jochum, Rahel Huch Boni, Gabriel P. Krestin, Philipp U. Heitz, and Dieter Hauri "Morphological changes after Nd:YAG laser treatment of the human prostate with the SideFocus fiber: correlation to MRI and impact of dosimetry and time", Proc. SPIE 2970, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII, (22 May 1997); https://doi.org/10.1117/12.275070

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KEYWORDS

Prostate

Magnetic resonance imaging

Laser therapeutics

Laser applications

Laser tissue interaction

Chemical oxygen iodine lasers

Laser ablation

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