Fluorescence ratio mapping system for tissue diagnosis

Alvin Katz; Howard E. Savage; Fanan Zeng; Jayson Rone; Gui Chen Tang; D. Harris; Jason A. Koutcher M.D.; Stimson P. Schantz M.D.; Robert R. Alfano

doi:10.1117/12.305363

16 April 1998 Fluorescence ratio mapping system for tissue diagnosis

Alvin Katz, Howard E. Savage, Fanan Zeng, Jayson Rone, Gui Chen Tang, D. Harris, Jason A. Koutcher M.D., Stimson P. Schantz M.D., Robert R. Alfano

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Proceedings Volume 3250, Optical Biopsy II; (1998) https://doi.org/10.1117/12.305363
Event: BiOS '98 International Biomedical Optics Symposium, 1998, San Jose, CA, United States

Abstract

A real time fluorescence ratio mapping a system for evaluating the surface of tissue can detect changes in tissue state including precancerous conditions. This system, using a personal computer and video camera, functions in near real-time, displaying pseudo color fluorescence intensity ratios maps at 15 frames per second. A fluorescence ratio mapping system functioning at close to video rates can be integrated with an endoscope to give the physician additional information during a patient exam about the state of a tissue. Preliminary measurements on ex vivo samples differentiated tumor from normal regions of tissues. Fluorescence spectral ratio maps give more structural detail of tissue than direct white light viewing. Tissue structure was observed in the fluorescence images. These results were correlated with histology.

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Alvin Katz, Howard E. Savage, Fanan Zeng, Jayson Rone, Gui Chen Tang, D. Harris, Jason A. Koutcher M.D., Stimson P. Schantz M.D., and Robert R. Alfano "Fluorescence ratio mapping system for tissue diagnosis", Proc. SPIE 3250, Optical Biopsy II, (16 April 1998); https://doi.org/10.1117/12.305363

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KEYWORDS

Tissues

Luminescence

Tissue optics

Tumors

Breast

Imaging systems

Video

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