Photodynamic therapy with ultrafast lasers

Eric A. Wachter; Mark G. Petersen; Craig Dees

doi:10.1117/12.351822

4 June 1999 Photodynamic therapy with ultrafast lasers

Eric A. Wachter, Mark G. Petersen, Craig Dees

Proceedings Volume 3616, Commercial and Biomedical Applications of Ultrafast Lasers; (1999) https://doi.org/10.1117/12.351822
Event: Optoelectronics '99 - Integrated Optoelectronic Devices, 1999, San Jose, CA, United States

Abstract

The photodynamic properties of several photosensitive compounds have been evaluated in vivo using simultaneous two-photon excitation (TPE) and multi-photon excitation (MPE). TPE and MPE are effected using a mode-locked laser, such as the mode-locked titanium:sapphire or Nd:YLF laser, the near infrared output of which allows direct promotion of various non-resonant transitions. Such lasers are exceptionally well suited for non-linear activation of exogenous or endogenous PDT agents in biological systems due to their extremely short pulse width, modest pulse energy, and high repetition rate; these features combine to effect efficient PDT activation with minimal potential for non- specific biological damage, improved spatial localization of activation, and enhanced depth of penetration. Results in several murine models are presented.

Citation Download Citation

Eric A. Wachter, Mark G. Petersen, and Craig Dees "Photodynamic therapy with ultrafast lasers", Proc. SPIE 3616, Commercial and Biomedical Applications of Ultrafast Lasers, (4 June 1999); https://doi.org/10.1117/12.351822

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