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26 February 2001 Cyclopeptide derivatives for molecular recognition
Birgit Kiesser, Dirk Nopper, Martin Herold, Guenter Gauglitz, Martin Elbs, Stefan Groeschel, Roland Brock, Guenter Jung
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Proceedings Volume 4205, Advanced Environmental and Chemical Sensing Technology; (2001) https://doi.org/10.1117/12.417434
Event: Environmental and Industrial Sensing, 2000, Boston, MA, United States
Abstract
Cyclohexapeptides were bound covalently to interference and gold layer and tested for recognition of amino acids in liquid phase. The peptides consist of three L -amino acids as variable building block. Attachment to the surface took place by reaction of the amino group in the side chain of L-cysteine. Reflectometric Interferance Spectroscopy (RIfS) was used for the determination of the interaction of aminoacids. Surface Plasmon Resonance (SPR) was used for validation and additional measurement with small peptides .Cyclopeptides with different side chains demonstrated distinct recognition pattern for different amino acids. The interaction was fast and reversible.
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Birgit Kiesser, Dirk Nopper, Martin Herold, Guenter Gauglitz, Martin Elbs, Stefan Groeschel, Roland Brock, and Guenter Jung "Cyclopeptide derivatives for molecular recognition", Proc. SPIE 4205, Advanced Environmental and Chemical Sensing Technology, (26 February 2001); https://doi.org/10.1117/12.417434
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KEYWORDS
Quantum wells
Biological and chemical sensing
Environmental sensing
Lithium
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