Nerve regeneration after femtosecond laser nanosurgery

Mehmet Fatih Yanik; Hulusi Cinar; Hediye Nese Cinar; Andrew D. Chisholm; Yishi Jin; Adela Ben-Yakar

doi:10.1117/12.613174

21 March 2005 Nerve regeneration after femtosecond laser nanosurgery

Mehmet Fatih Yanik, Hulusi Cinar, Hediye Nese Cinar, Andrew D. Chisholm, Yishi Jin, Adela Ben-Yakar

Proceedings Volume 5714, Commercial and Biomedical Applications of Ultrafast Lasers V; (2005) https://doi.org/10.1117/12.613174
Event: Lasers and Applications in Science and Engineering, 2005, San Jose, California, United States

Abstract

We demonstrate sub-micron scale surgery with femtosecond lasers in a tiny living organism. By just cutting few nano-scale nerve connections inside the nematode C. elegans, we succeeded to stop the whole animal from moving backwards. This delicate axotomy keeps the surrounding of the severed axons un-damaged so that the axons can regrow back, and the worms recover and can move backwards again. These results demonstrate, for the first time, nerve regeneration in such a tiny organism, in its evolutionarily simplest form. The ability to perform precise sub-micron scale axotomy on such organisms provides tremendous research potential for rapid screening of drugs and discovery of new biomolecules affecting regeneration and development.

Citation Download Citation

Mehmet Fatih Yanik, Hulusi Cinar, Hediye Nese Cinar, Andrew D. Chisholm, Yishi Jin, and Adela Ben-Yakar "Nerve regeneration after femtosecond laser nanosurgery", Proc. SPIE 5714, Commercial and Biomedical Applications of Ultrafast Lasers V, (21 March 2005); https://doi.org/10.1117/12.613174

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