Microfluidic valve geometries and possibilities for flow switching in gas chromatography

Philip J. Marriott; Graham T. Eyres; Sylvia Urban; Christian Rühle

doi:10.1117/12.814896

30 December 2008 Microfluidic valve geometries and possibilities for flow switching in gas chromatography

Philip J. Marriott, Graham T. Eyres, Sylvia Urban, Christian Rühle

Proceedings Volume 7270, Biomedical Applications of Micro- and Nanoengineering IV and Complex Systems; 72700G (2008) https://doi.org/10.1117/12.814896
Event: SPIE Smart Materials, Nano- and Micro-Smart Systems, 2008, Melbourne, Australia

Abstract

Classical multi-(two-)dimensional separations in gas chromatography (GC) require switching systems to transfer the gas flow stream from the first to second dimension. This can be accomplished by valve systems, but is more suitably effected by pressure balanced systems, such as the Deans' switch method. Recent developments in microfluidics and related micro-technologies should make gas phase switching much more effective. The capillary flow technology platform of Agilent Technologies is an example of recent developments introduced to GC. Thus various Deans' switch pressure balanced devices, stream splitters, and column couplings bring new capabilities to analytical GC. We are uniquely placed to take advantage of the new devices, owing to our development of advanced operational methods in GC which can make use of microfluidic capillary couplings, and novel cryogenic approaches that deliver performance previously impossible with conventional methods. Multidimensional chromatographic flow switching to isolate pure compounds from complex mixtures suggests many potential applications for enhanced chemical analysis. Multiple dimensions of GC analysis, capabilities for integrating different spectroscopic detection methods for chemical identification of isolated chemical species including mass spectrometry, nuclear magnetic resonance and Fourier transform infrared, can be proposed. Applications in the essential oils and petrochemical area will be outlined.

Citation Download Citation

Philip J. Marriott, Graham T. Eyres, Sylvia Urban, and Christian Rühle "Microfluidic valve geometries and possibilities for flow switching in gas chromatography", Proc. SPIE 7270, Biomedical Applications of Micro- and Nanoengineering IV and Complex Systems, 72700G (30 December 2008); https://doi.org/10.1117/12.814896

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available