Peptide-modified gold nanoparticles for improved cancer therapeutics

Celina Yang; Monique Van Prooijen; Devika B. Chithrani

doi:10.1117/12.2040309

24 March 2014 Peptide-modified gold nanoparticles for improved cancer therapeutics

Celina Yang, Monique Van Prooijen, Devika B. Chithrani

Proceedings Volume 8955, Colloidal Nanoparticles for Biomedical Applications IX; 89550E (2014) https://doi.org/10.1117/12.2040309
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

The field of nanotechnology is currently undergoing explosive development on many fronts. The technology is expected to generate innovations and play a critical role in cancer therapeutics. Among other nanoparticle (NP) systems, there has been tremendous progress made in the use of spherical gold NPs (GNPs) in cancer therapeutics. In treating cancer, radiation therapy and chemotherapy remain the most widely used treatment options. These nanostructures further provide strategies for improving loading, targeting, and controlling the release of drugs to minimize the side effects of highly toxic anticancer drugs used in chemotherapy. Our recent results show enhancement of cell death during radiation therapy when GNPs are targeted to nucleus. In addition, we have seen enhanced therapeutic effects when GNPs are used as anticancer drug carriers. Hence, gold nanostructures provide a versatile platform to integrate many therapeutic options leading to effective combinational therapy in the fight against cancer. A multifunctional platform based on gold nanostructures with targeting ligands, therapeutic molecules, and imaging contrast agents will hold the possibility of promising directions in cancer research.

Citation Download Citation

Celina Yang, Monique Van Prooijen, and Devika B. Chithrani "Peptide-modified gold nanoparticles for improved cancer therapeutics", Proc. SPIE 8955, Colloidal Nanoparticles for Biomedical Applications IX, 89550E (24 March 2014); https://doi.org/10.1117/12.2040309

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