Two-color imaging of vital nerve structures with applications in fluorescence-guided surgery using near-infrared fluorophores with improved physicochemical properties

Antonio R. Montaño; Anas Masillati; Lei G. Wang; Dani Szafran-Reeder; Connor W. Barth; Nourhan A. Shams; Summer L. Gibbs

doi:10.1117/12.2648521

17 March 2023 Two-color imaging of vital nerve structures with applications in fluorescence-guided surgery using near-infrared fluorophores with improved physicochemical properties

Antonio R. Montaño, Anas Masillati, Lei G. Wang, Dani Szafran-Reeder, Connor W. Barth, Nourhan A. Shams, Summer L. Gibbs

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Proceedings Volume PC12361, Molecular-Guided Surgery: Molecules, Devices, and Applications IX; PC123610K (2023) https://doi.org/10.1117/12.2648521
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Iatrogenic nerve injury is a major source of morbidity common to all surgical specialties. Prostate cancer, the second leading cause of cancer-related death among men in the U.S, is often treated surgically via prostatectomy. But visibility of the nerve plexus is extremely limited and nerve damage affects 60% of patients leading to post-surgical comorbidities. We’ve developed a synthetic strategy to improve key properties of fluorophores with potential clinical translatability to generate an optimal 700 nm fluorophore to pair with a fluorescently labeled probe optimized for the 800 nm channel in FGS systems targeting PSMA via the EUK targeting sequence for use in two-color prostatectomy. These new water-soluble, NIR, nerve-specific fluorophores show improved nerve specificity and in vivo brightness, require a lower dose to achieve contrast of superficial and buried nerve tissue and negate formulation development, improving safety profiles and lowering the cost of clinical translation.

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Antonio R. Montaño, Anas Masillati, Lei G. Wang, Dani Szafran-Reeder, Connor W. Barth, Nourhan A. Shams, and Summer L. Gibbs "Two-color imaging of vital nerve structures with applications in fluorescence-guided surgery using near-infrared fluorophores with improved physicochemical properties", Proc. SPIE PC12361, Molecular-Guided Surgery: Molecules, Devices, and Applications IX, PC123610K (17 March 2023); https://doi.org/10.1117/12.2648521

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KEYWORDS

Nerve

Surgery

Cancer

Prostate cancer

Lead

Near infrared

Prostate

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