CONFERENCE PROCEEDINGS
Advanced Search
Home > Proceedings > Volume PC12398 > Article
Presentation
17 March 2023 NIR I cyanine dyes complexed with engineered albumin fragments for NIR II fluorescence imaging (Conference Presentation)
Xiaoyuan Chen
Author Affiliations +
Proceedings Volume PC12398, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XIV; PC1239801 (2023) https://doi.org/10.1117/12.2653799
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
This talk will highlight a genetic engineering technique to obtain a series of albumin fragments and recombinant proteins containing one or multiple domains that form covalent bonds with chloro-containing cyanine dyes. These albumin variants protect the inserted dyes and remarkably enhance their brightness. The albumin variants can also be genetically edited to develop size-tunable complexes with precisely tailored pharmacokinetics. The proteins can also be conjugated to biofunctional molecules without impacting the complexed dyes. This combination of albumin mutants and clinically-used cyanine dyes can help widen the clinical application prospects of NIR I fluorophores to be visualized in the NIR II window.
Conference Presentation
© (2023) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation Download Citation
Xiaoyuan Chen "NIR I cyanine dyes complexed with engineered albumin fragments for NIR II fluorescence imaging (Conference Presentation)", Proc. SPIE PC12398, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XIV, PC1239801 (17 March 2023); https://doi.org/10.1117/12.2653799
ACCESS THE FULL ARTICLE
ORGANIZATIONAL
Sign in with credentials provided by your organization.
INSTITUTIONAL
Select your institution to access the SPIE Digital Library.
SELECT YOUR INSTITUTION
PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
PERSONAL SIGN IN
No SPIE Account? Create one
PURCHASE THIS CONTENT
SUBSCRIBE TO DIGITAL LIBRARY
50 downloads per 1-year subscription
Members: $195
Non-members: $335 ADD TO CART
25 downloads per 1 - year subscription
Members: $145
Non-members: $250 ADD TO CART
PURCHASE SINGLE ARTICLE
Includes PDF, HTML & Video, when available
Members: $17.00
Non-members: $21.00 ADD TO CART
PROCEEDINGS
 PRESENTATION
WATCH
PRESENTATION SAVE TO MY LIBRARY
GET CITATION
Advertisement
Advertisement
KEYWORDS
Near infrared
Luminescence
Dysprosium
Molecules
Proteins
Genetic engineering
Indium gallium arsenide
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top