Symmetry breaking at cellular adhesion complexes

Alexander Dunn

doi:10.1117/12.2682475

5 October 2023 Symmetry breaking at cellular adhesion complexes

Alexander Dunn

Proceedings Volume PC12649, Optical Trapping and Optical Micromanipulation XX; PC1264905 (2023) https://doi.org/10.1117/12.2682475
Event: SPIE Nanoscience + Engineering, 2023, San Diego, California, United States

Abstract

Multicellular tissues are a defining feature of animal life, but how tissue-level organization arises from the interactions of the individual proteins present at intercellular adhesion complexes remains incompletely understood. In this talk, I will describe single-molecule optical trap experiments that reveal the molecular mechanisms by which proteins present at cellular adhesion complexes help to seed long-range order in the cytoskeleton, and by extension, in multicellular tissues. These and other findings support an emerging understanding of how cells regulate cellular adhesion in space and time to generate tissues that are both dynamic and physically robust.

Conference Presentation

Citation Download Citation

Alexander Dunn "Symmetry breaking at cellular adhesion complexes", Proc. SPIE PC12649, Optical Trapping and Optical Micromanipulation XX, PC1264905 (5 October 2023); https://doi.org/10.1117/12.2682475

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