Presentation
13 March 2024 Fast hyperspectral SRS for analysis of drug tablet formulation
Yuxiao Wei, Isaac J Pence, Conor L Evans
Author Affiliations +
Abstract
Pharmaceutical development of solid-state formulations requires testing for uniformity and stability of active pharmaceutical ingredients and excipients. Solid-state properties such as component distribution and grain size are crucial factors of dissolution profile, which greatly affect drug efficacy and toxicity, and can only be analyzed spatially by chemical imaging (CI) techniques. Current CI techniques such as near infrared and confocal Raman spectroscopy do not offer high chemical and spatial resolution at speeds feasible for integration into the pharmaceutical quality control and quality assurance processes. We demonstrate fast chemical imaging by epi-detected sparse spectral sampling stimulated Raman scattering to quantify API and excipient degradation and distribution.
Conference Presentation
© (2024) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Yuxiao Wei, Isaac J Pence, and Conor L Evans "Fast hyperspectral SRS for analysis of drug tablet formulation", Proc. SPIE PC12821, Visualizing and Quantifying Drug Distribution in Tissue VIII, PC128210C (13 March 2024); https://doi.org/10.1117/12.3001829
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KEYWORDS
Raman scattering

Tablets

Microscopy

Solids

Visualization

Chemical analysis

Imaging spectroscopy

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