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13 March 2024 Dissolving microneedles with ALA for topical PDT optimization: characterization and pre-clinical tests
Michelle B. Requena, Dianeth Sara Lima Bejar, Thaila Quatrini Corrêa, Juliana Cristina Barreiro, Vanderlei Salvador Bagnato
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Proceedings Volume PC12823, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXII; PC1282307 (2024) https://doi.org/10.1117/12.3004461
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Dissolving microneedles (DMNs) is a non-invasive intradermal or systemic drug delivery system. Considering topical photodynamic therapy (PDT) for non-melanoma skin cancer treatment, limited cream permeation is one of the main issues. In this context, DMNs can improve the prodrugs permeation providing photosensitizer distribution within lesions. This study explored DMNs containing aminolevulinic acid (ALA) with Gantrez AN-139 considering manufacturing protocols, mechanical resistance, insertion capability, ALA distribution homogeneity, and performance in a human xenographic tumor model induced in balb/c mice.
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Michelle B. Requena, Dianeth Sara Lima Bejar, Thaila Quatrini Corrêa, Juliana Cristina Barreiro, and Vanderlei Salvador Bagnato "Dissolving microneedles with ALA for topical PDT optimization: characterization and pre-clinical tests", Proc. SPIE PC12823, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXII, PC1282307 (13 March 2024); https://doi.org/10.1117/12.3004461
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KEYWORDS
Photodynamic therapy
In vitro testing
Polymers
Imaging spectroscopy
In vivo imaging
Manufacturing
Resistance
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