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19 March 2024 Real-time photodynamic therapy monitoring with ultrasound-guided photoacoustic imaging
Andrew Langley, Allison Sweeney, Brooke Bednarke, Faizah Wulandana, Srivalleesha Mallidi
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Proceedings Volume PC12823, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXII; PC128230E (2024) https://doi.org/10.1117/12.3003211
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
As photodynamic therapy is reliant on endogenous tumor oxygen to be successful, personalizing treatment to the patient is a necessary step to improving overall efficacy. We have demonstrated the feasibility of functionally imaging PDT in real-time, by mapping oxygen saturation as a surrogate marker for PDT progression with ultrasound-guided photoacoustic imaging in vivo. Particularly, we have deciphered the spatial map of the oxygen depletion rate during PDT as a function of fluence rate. Photoacoustic imaging importantly provides the temporal and spatial resolution, providing a novel platform for monitoring that can be used to inform personalized treatment in future work.
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Andrew Langley, Allison Sweeney, Brooke Bednarke, Faizah Wulandana, and Srivalleesha Mallidi "Real-time photodynamic therapy monitoring with ultrasound-guided photoacoustic imaging", Proc. SPIE PC12823, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXII, PC128230E (19 March 2024); https://doi.org/10.1117/12.3003211
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KEYWORDS
Photodynamic therapy
Photoacoustic imaging
Optical sensing
Oxygen
Optical fibers
Oxygenation
Systems modeling
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