Our prior work has established that SFDI metrics can be used to assess skin involvement in scleroderma. To ease clinical translation of SFDI for SSc disease assessment, a preliminary design for a handheld SFDI system optimized for measurement of sclerodermatous skin is proposed. An LED is used as an illumination source, light is modulated using a printed transparency, and Rd is extracted using single snapshot demodulation methods. Additionally, the imager can measure scattering orientation using a rotating pattern. The performance of the imager was assessed using phantoms, and its inter- and intra-observer reliabilities were assessed.
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