Miniature-scope based optical coherence tomograph brain imaging on mice

Jingyi Wang; Lidek Chou; Zhongping Chen

doi:10.1117/12.3003408

13 March 2024 Miniature-scope based optical coherence tomograph brain imaging on mice

Jingyi Wang, Lidek Chou, Zhongping Chen

Proceedings Volume PC12828, Neural Imaging and Sensing 2024; PC128280I (2024) https://doi.org/10.1117/12.3003408
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Optical brain imaging has several advantages over other imaging techniques and was used to visualize both the structural and functional aspects of the brain, providing a more complete picture of brain activity. One of the promising techniques is optical coherence tomography (OCT), which uses low-coherence interferometry to obtain three-dimensional depth-resolved imaging of structures. In this research, we proposed a micro-electro-mechanical (MEMS) based miniature OCT probe and conducted brain imaging at the hippocampus area. The designed probe has great potential applied to freely moving mice that can observe the changes in brain structure and vascular, thus aimed at early detection of Alzheimer's disease.

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Jingyi Wang, Lidek Chou, and Zhongping Chen "Miniature-scope based optical coherence tomograph brain imaging on mice", Proc. SPIE PC12828, Neural Imaging and Sensing 2024, PC128280I (13 March 2024); https://doi.org/10.1117/12.3003408

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KEYWORDS

Optical coherence tomography

Brain

Brain imaging

Neuroimaging

Optical coherence

Biological imaging

Blood vessels

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