Intelligent micro-electrodes arrays for biofluids analysis—towards real-time precision medicine

Dayananda Desagani; Ahed Shibli; Avigayil Zerem; Avia Lavon; Alex Snezhko; Hadar Ben-Yoav

doi:10.1117/12.3008620

5 April 2024 Intelligent micro-electrodes arrays for biofluids analysis—towards real-time precision medicine

Dayananda Desagani, Ahed Shibli, Avigayil Zerem, Avia Lavon, Alex Snezhko, Hadar Ben-Yoav

Proceedings Volume PC12837, Microfluidics, BioMEMS, and Medical Microsystems XXII; PC1283707 (2024) https://doi.org/10.1117/12.3008620
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

We report a new electrochemical bio-microelectromechanical system that will enable biofluids analysis without pretreatment steps and lies in the use of an array of microelectrodes modified with bioelectronic nano-films. The multi-sensor array generates a set of complex electrochemical signals that is analyzed by using intelligent machine learning algorithms (‘chemometrics’). Here, we demonstrate the in-situ detection of: (1) the neurotransmitter dopamine in undiluted urine (a biomarker for adrenal cancer); (2) the antipsychotic clozapine in blood to provide improved schizophrenia treatment outcomes; and (3) the drug hydroxyurea in blood to enable optimized treatment of children affected with sickle cell disease.

Conference Presentation

Citation Download Citation

Dayananda Desagani, Ahed Shibli, Avigayil Zerem, Avia Lavon, Alex Snezhko, and Hadar Ben-Yoav "Intelligent micro-electrodes arrays for biofluids analysis—towards real-time precision medicine", Proc. SPIE PC12837, Microfluidics, BioMEMS, and Medical Microsystems XXII, PC1283707 (5 April 2024); https://doi.org/10.1117/12.3008620

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