Quantitative evaluation of optical coherence tomography signal enhancement with gold nanoshells

Agrawal, Anant; Huang, Stanley; Wei Haw Lin, Alex; Lee, Min-Ho; Barton, Jennifer K.; Drezek, Rebekah A.; Pfefer, T. Joshua

doi:doi:10.1117/1.2339071

My Subscription | My Email Alerts | My Article Collections

GENERAL INFORMATION

You are not logged in Logged Out Log In

Journal of Biomedical Optics / Volume 11 / Issue 4 / Special Section on Pioneers in Biomedical Optics: A.J. Welch

Previous Article | Next Article

Quantitative evaluation of optical coherence tomography signal enhancement with gold nanoshells

J. Biomed. Opt. 11, 041121 (Sep 06, 2006); doi:10.1117/1.2339071

Alerts
- Alert Me When Cited
- Alert Me When Corrected
Tools
Share
- Email Abstract
- Connotea
- CiteULike
- del.icio.us
- BibSonomy
- Tweet this Article
- Add to Facebook

Abstract

References (35)

Citing Articles (28)

Anant Agrawal and T. Joshua Pfefer

US Food and Drug Administration, Center for Devices and Radiological Health, Optical Diagnostics Laboratory, 12725 Twinbrook Parkway, HFZ-130, Rockville, Maryland 20852

Stanley Huang

Johns Hopkins University, Department of Biomedical Engineering, 318 Clark Hall, 3400 N. Charles Street, Baltimore, Maryland 21218

Alex Wei Haw Lin, Min-Ho Lee, and Rebekah A. Drezek

Rice University, Department of Bioengineering, PO Box 1892, MS-142, Houston, Texas 77251-1892

Jennifer K. Barton

The University of Arizona, Division of Biomedical Engineering, 1230 E Speedway Boulevard, Tucson, Arizona 85721-0104

Nanoshell-enhanced optical coherence tomography (OCT) is a novel technique with the potential for molecular imaging and improved disease detection. However, optimization of this approach will require a quantitative understanding of the influence of nanoshell parameters on detected OCT signals. In this study, OCT was performed at 1310 nm in water and turbid tissue-simulating phantoms to which nanoshells were added. The effect of nanoshell concentration, core diameter, and shell thickness on signal enhancement was characterized. Experimental results indicated trends that were consistent with predicted optical properties−a monotonic increase in signal intensity and attenuation with increasing shell and core size. Threshold concentrations for a 2-dB OCT signal intensity gain were determined for several nanoshell geometries. For the most highly backscattering nanoshells tested−291-nm core diameter, 25-nm shell thickness−a concentration of 10⁹ nanoshells/mL was needed to produce this signal increase. Based on these results, we discuss various practical considerations for optimizing nanoshell-enhanced OCT. Quantitative experimental data presented here will facilitate optimization of OCT-based diagnostics and may also be relevant to other reflectance-based approaches as well.

History

Received Sep 30, 2005
Accepted Apr 11, 2006
Revised Feb 24, 2006
Published online Sep 06, 2006

Permalink

http://dx.doi.org/10.1117/1.2339071

Citation

Anant Agrawal, Stanley Huang, Alex Wei Haw Lin, Min-Ho Lee, Jennifer K. Barton, Rebekah A. Drezek and T. Joshua Pfefer, "Quantitative evaluation of optical coherence tomography signal enhancement with gold nanoshells", J. Biomed. Opt. 11, 041121 (Sep 06, 2006); doi:10.1117/1.2339071