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Journal of Biomedical Optics / Volume 13 / Issue 6 / JBO Letters

Cost-effective diffuse reflectance spectroscopy device for quantifying tissue absorption and scattering in vivo

J. Biomed. Opt. 13, 060505 (Dec 15, 2008); http://dx.doi.org/10.1117/1.3041500

Bing Yu, Justin Y. Lo, Janelle E. Bender, and Nirmala Ramanujam

Duke University, Department of Biomedical Engineering, Durham, North Carolina 27708

Thomas F. Kuech

University of Wisconsin, Department of Chemical and Biological Engineering, Madison, Wisconsin 53706

Gregory M. Palmer

Duke University, Department of Radiation Oncology, Durham, North Carolina 27708

A hybrid optical device that uses a multimode fiber coupled to a tunable light source for illumination and a 2.4-mm photodiode for detection in contact with the tissue surface is developed as a first step toward our goal of developing a cost-effective, miniature spectral imaging device to map tissue optical properties in vivo. This device coupled with an inverse Monte Carlo model of reflectance is demonstrated to accurately quantify tissue absorption and scattering in tissue-like turbid synthetic phantoms with a wide range of optical properties. The overall errors for quantifying the absorption and scattering coefficients are 6.0±5.6 and 6.1±4.7%, respectively. Compared with fiber-based detection, having the detector right at the tissue surface can significantly improve light collection efficiency, thus reducing the requirement for sophisticated detectors with high sensitivity, and this design can be easily expanded into a quantitative spectral imaging system for mapping tissue optical properties in vivo.

© 2008 Society of Photo-Optical Instrumentation Engineers

History
Received Jul 15, 2008
Accepted Oct 17, 2008
Revised Sep 24, 2008
Published online Dec 15, 2008
Digital Object Identifier
http://dx.doi.org/10.1117/1.3041500
Citation
Bing Yu, Justin Y. Lo, Thomas F. Kuech, Gregory M. Palmer, Janelle E. Bender and Nirmala Ramanujam, "Cost-effective diffuse reflectance spectroscopy device for quantifying tissue absorption and scattering in vivo", J. Biomed. Opt. 13, 060505 (Dec 15, 2008); http://dx.doi.org/10.1117/1.3041500

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