Nanophotothermolysis of multiple scattered cancer cells with carbon nanotubes guided by time-resolved infrared thermal imaging

Biris, Alexandru S.; Boldor, Dorin; Palmer, Jason; Monroe, William T.; Mahmood, Meena; Dervishi, Enkeleda; Xu, Yang; Li, Zhongrui; Galanzha, Ekaterina I.; Zharov, Vladimir P.

doi:doi:10.1117/1.3119135

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Journal of Biomedical Optics / Volume 14 / Issue 2 / Special Section on Nanophotonics for Diagnostics, Protection, and Treatment of Cancer and Inflammatory Diseases

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Nanophotothermolysis of multiple scattered cancer cells with carbon nanotubes guided by time-resolved infrared thermal imaging

J. Biomed. Opt. 14, 021007 (Apr 28, 2009); http://dx.doi.org/10.1117/1.3119135

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Abstract

References (21)

Citing Articles (10)

Alexandru S. Biris, Meena Mahmood, Enkeleda Dervishi, Yang Xu, and Zhongrui Li

University of Arkansas at Little Rock, Applied Science Department, Nanotechnology Center, Little Rock, Arkansas 72204

Dorin Boldor, Jason Palmer, and William T. Monroe

Louisiana State University Agricultural Center, Department of Biological and Agricultural Engineering, Baton Rouge, Louisiana 70803

Ekaterina I. Galanzha and Vladimir P. Zharov

University of Arkansas for Medical Sciences, Philips Classic Laser and Nanomedicine Laboratories, Little Rock, Arkansas 72205

Nanophotothermolysis with long laser pulses for treatment of scattered cancer cells and their clusters is introduced with the main focus on real-time monitoring of temperature dynamics inside and around individual cancer cells labeled with carbon nanotubes. This technique utilizes advanced time- and spatially-resolved thermal radiometry imaging for the visualization of laser-induced temperature distribution in multiple-point absorbing targets. The capability of this approach was demonstrated for monitoring of thermal effects under long laser exposure (from millisecond to seconds, wavelength 1064 nm, maximum power 1 W) of cervical cancer HeLa cells labeled with carbon nanotubes in vitro. The applications are discussed with a focus on the nanophotothermolysis of small tumors, tumor margins, or micrometastases under the guidance of near-IR and microwave radiometry.

History

Received Sep 09, 2008
Accepted Feb 14, 2009
Revised Jan 17, 2009
Published online Apr 28, 2009

Digital Object Identifier

http://dx.doi.org/10.1117/1.3119135

Citation

Alexandru S. Biris, Dorin Boldor, Jason Palmer, William T. Monroe, Meena Mahmood, Enkeleda Dervishi, Yang Xu, Zhongrui Li, Ekaterina I. Galanzha and Vladimir P. Zharov, "Nanophotothermolysis of multiple scattered cancer cells with carbon nanotubes guided by time-resolved infrared thermal imaging", J. Biomed. Opt. 14, 021007 (Apr 28, 2009); http://dx.doi.org/10.1117/1.3119135