Photoacoustic molecular imaging with antibody-functionalized single-walled carbon nanotubes for early diagnosis of tumor

Xiang, Liangzhong; Yuan, Yi; Xing, Da; Ou, Zhongmin; Yang, Sihua; Zhou, Feifan

doi:doi:10.1117/1.3078809

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Journal of Biomedical Optics / Volume 14 / Issue 2 / Special Section on Nanophotonics for Diagnostics, Protection, and Treatment of Cancer and Inflammatory Diseases

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Photoacoustic molecular imaging with antibody-functionalized single-walled carbon nanotubes for early diagnosis of tumor

J. Biomed. Opt. 14, 021008 (Mar 04, 2009); http://dx.doi.org/10.1117/1.3078809

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Abstract

References (19)

Citing Articles (21)

Liangzhong Xiang, Yi Yuan, Da Xing, Zhongmin Ou, Sihua Yang, and Feifan Zhou

South China Normal University, Ministry of Education, Key Laboratory of Laser Life Science and Institute of Laser Life Science, Guangzhou 510631, China

Single-walled carbon nanotubes (SWNT) in a poly(ethylene)ghycol solution are a biocompatible transporters with strong optical absorption in the near-infrared region, in which the biological tissue is almost transparent with very low absorbance. Here, antibody-functionalized SWNTs for tumor early detection with photoacoustic molecular imaging in vivo are reported. To lay the groundwork for this goal and insure system stability, images were collected in tissue simulating phantoms to determine appropriate detectable concentrations of SWNTs. Preliminary in vitro and in vivo results showed that a high contrast and a high efficient targeting of integrin α_vβ₃ positive U87 human glioblastoma tumours in mice could be achieved. The nontoxicity of functionalized SWNTs has also been demonstrated in our experiment; this feature ensures that SWNTs can be used for clinical applications. This study suggests that photoacoustic molecular imaging with antibody-functionalized SWNTs has the potential to be an effective early tumor diagnosis method.

History

Received Jul 15, 2008
Accepted Nov 15, 2008
Revised Nov 13, 2008
Published online Mar 04, 2009

Digital Object Identifier

http://dx.doi.org/10.1117/1.3078809

Citation

Liangzhong Xiang, Yi Yuan, Da Xing, Zhongmin Ou, Sihua Yang and Feifan Zhou, "Photoacoustic molecular imaging with antibody-functionalized single-walled carbon nanotubes for early diagnosis of tumor", J. Biomed. Opt. 14, 021008 (Mar 04, 2009); http://dx.doi.org/10.1117/1.3078809