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Journal of Biomedical Optics / Volume 14 / Issue 5 / Research Papers

Specific immobilization of influenza A virus on GaAs (001) surface

J. Biomed. Opt. 14, 054042 (Oct 26, 2009); http://dx.doi.org/10.1117/1.3251057

Valerie Duplan and Jan J. Dubowski

Université de Sherbrooke, Department of Electrical and Computer Engineering, Faculty of Engineering, Sherbrooke, Québec J1K2R1, Canada

Yannick Miron and Michel Grandbois

Université de Sherbrooke, Department of Pharmacology, Faculty of Medicine and Health Sciences, Sherbrooke, Québec J1H5N4, Canada

Eric Frost

Université de Sherbrooke, Department of Microbiology and Infectiology, Faculty of Medicine and Health Sciences, Sherbrooke, Québec J1H5N4, Canada

In the quest for the development of an all-optical biosensor for rapid detection and typing of viral pathogens, we investigate biosensing architectures that take advantage of strong photoluminescence emission from III-V quantum semiconductors (QS). One of the key elements in the development of such a biosensor is the ability to attach various analytes to GaAs—a material of choice for capping III-V QS of our interest. We report on the study of biofunctionalization of GaAs (001) with polyethylene-glycol (PEG) thiols and the successful immobilization of influenza A virus. A diluted solution of biotinylated PEG thiols in OH-terminated PEG thiols is used to form a network of sites for the attachment of neutravidin. Biotinylated polyclonal influenza A antibodies are applied to investigate the process of the immobilization of inactivated influenza A virus. The successful immobilization is demonstrated using atomic force microscopy and fluorescence microscopy measurements.

© 2009 Society of Photo-Optical Instrumentation Engineers

History
Received Apr 21, 2009
Accepted Aug 27, 2009
Revised Aug 25, 2009
Published online Oct 26, 2009
Digital Object Identifier
http://dx.doi.org/10.1117/1.3251057
Citation
Valerie Duplan, Yannick Miron, Eric Frost, Michel Grandbois and Jan J. Dubowski, "Specific immobilization of influenza A virus on GaAs (001) surface", J. Biomed. Opt. 14, 054042 (Oct 26, 2009); http://dx.doi.org/10.1117/1.3251057

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