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Journal of Biomedical Optics / Volume 16 / Issue 4 / JBO Letters

Quantitative analysis on collagen morphology in aging skin based on multiphoton microscopy

J. Biomed. Opt. 16, 040502 (Apr 14, 2011); http://dx.doi.org/10.1117/1.3565439

Shulian Wu, Hui Li, Hongqin Yang, Xiaoman Zhang, Zhifang Li, and Shufei Xu

Fujian Normal University, School of Physics and OptoElectronics Technology, Institute of Laser and Optoelectronics Technology, Fujian Provincial Key Laboratory of Photonics Technology, Key Lab of OptoElectronic Science and Technology for Medicine, Ministry of Education, Fuzhou 350007, China

Multiphoton microscopy was employed for monitoring the structure changes of mouse dermis collagen in the intrinsic- or the extrinsic-age-related processes in vivo. The characteristics of textures in different aging skins were uncovered by fast Fourier transform in which the orientation index and bundle packing of collagen were quantitatively analyzed. Some significant differences in collagen-related changes are found in different aging skins, which can be good indicators for the statuses of aging skins. The results are valuable to the study of aging skin and also of interest to biomedical photonics.

© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE)

History
Received Oct 12, 2010
Accepted Feb 17, 2011
Revised Feb 16, 2011
Published online Apr 14, 2011
Digital Object Identifier
http://dx.doi.org/10.1117/1.3565439
Citation
Shulian Wu, Hui Li, Hongqin Yang, Xiaoman Zhang, Zhifang Li and Shufei Xu, "Quantitative analysis on collagen morphology in aging skin based on multiphoton microscopy", J. Biomed. Opt. 16, 040502 (Apr 14, 2011); http://dx.doi.org/10.1117/1.3565439

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